Fiber (Cellulose)
Latin: fibra – fiber
Fibers, particularly cellulose, are complex carbohydrates that form the structural components of plant cell walls. Cellulose is a polysaccharide composed of long chains of glucose molecules linked by β-1,4-glycosidic bonds, making it indigestible to humans due to the lack of necessary enzymes. Because it cannot be broken down in the small intestine, cellulose passes into the colon where it can cause inflammation and irritation of the gut lining.
This causes enlarged stools, constipation, and contributes to disorders including irritable bowel syndrome and an increased risk of colorectal cancer. Furthermore, prolonged damage to the mucous membranes of the intestines caused by excessive or harsh fiber intake can impair nutrient absorption, contributing to malnutrition, especially as people age.
Summary
Fiber, derived from the Latin fibra meaning "fiber," primarily refers to cellulose, a complex carbohydrate and a key structural component of plant cell walls. Chemically, cellulose is a polysaccharide made up of long chains of glucose units linked by β-1,4-glycosidic bonds, rendering it indigestible to humans due to the absence of the enzymes required to break these bonds. Unlike other carbohydrates, cellulose passes largely unchanged through the small intestine and enters the colon.
Absorption & Damage within the intestines
Humans lack the enzymes necessary to break down cellulose, so it passes unchanged into the colon, where its abrasive, insoluble fibers physically damage the delicate mucous lining of the intestines. This constant mechanical irritation causes inflammation, thickening, and scarring of the gut wall, impairing nutrient absorption—a problem that worsens with age, leading to malnutrition and frailty.
Beyond the mechanical damage, bacterial fermentation of certain fibers produces acids—such as lactic and acetic acid—that lower the pH in the colon. While fermentation of soluble fibers is often portrayed as beneficial, excessive acidification actually harms our native beneficial gut flora, weakening this critical microbial ecosystem and allowing opportunistic pathogens to thrive. This imbalance further promotes inflammation and disrupts gut barrier function.
The bulk created by cellulose not only hardens stools but also increases strain during defecation, contributing to constipation and exacerbating conditions like irritable bowel syndrome (IBS). Chronic irritation and inflammation caused by fiber intake are implicated in a higher risk of colorectal cancer, undermining the widespread claim that all fiber supports colon health. The evidence clearly indicates that rather than being universally protective, insoluble fiber can be a source of gut distress and long-term health risks.
Negative effects
Indigestible bulk: Passes unchanged through the gut, causing mechanical abrasion to the intestinal lining.
Gut irritation: Chronic abrasion leads to inflammation, mucosal damage, and reduced nutrient absorption.
Microbiota disruption: Fermentation acids lower colon pH, harming beneficial bacteria and promoting harmful microbes.
Constipation and bowel strain: Increases stool hardness and size, worsening constipation and IBS symptoms.
Colorectal cancer risk: Long-term inflammation from fiber abrasion linked to higher cancer risk.
Malnutrition in elderly: Damage to gut lining impairs nutrient uptake, increasing frailty with age.
Overhyped benefits: Fiber’s universal health claims overlook individual gut sensitivity and potential harm.
Chemical Structure
Molecular formula: (C₆H₁₀O₅)ₙ (where n indicates the degree of polymerization, typically several hundred to thousands)
Molecular mass: Variable, depending on polymer length; ranges from tens to hundreds of thousands of atomic mass units (amu)
Atomic composition: Carbon (C), Hydrogen (H), Oxygen (O)
Bond types:
C–C and C–H bonds: Single covalent (sigma, σ) bonds within glucose monomers
C–O bonds: Single covalent bonds linking carbon and oxygen atoms in the glucose ring and glycosidic linkages
Glycosidic bonds (β-1,4-glycosidic linkages): Covalent bonds connecting glucose units in a linear chain
Functional groups:
Hydroxyl groups (–OH) on each glucose monomer, responsible for extensive hydrogen bonding
Ether linkage (glycosidic bond) between C1 of one glucose and C4 of the adjacent glucose unit (β-1,4 linkage)
Bond order:
Single bonds (bond order 1) dominate the polymer structure
Bond length:
C–C bond length ~154 pm
C–O bond length ~143 pm
O–H bond length ~96 pm
Electron configuration (typical carbon atom): 1s² 2s² 2p²
Molecular polarity: Polar due to abundant hydroxyl groups capable of hydrogen bonding
Solubility: Insoluble in water due to strong inter- and intra-molecular hydrogen bonding forming crystalline microfibrils
Functionality: Provides structural support in plant cell walls; indigestible by humans due to β-1,4 linkages
Physiological Damage of Fiber (Cellulose)
Mechanical Irritation and Chronic Inflammation
Cellulose is indigestible and abrasive, causing repeated mechanical irritation to the intestinal mucosa, leading to micro-injuries and chronic inflammation. This compromises gut barrier integrity, impairing nutrient absorption and promoting disease.
Reference: Bueno et al., 2012. Mechanical irritation by insoluble fiber exacerbates intestinal inflammation. Inflamm Bowel Dis. [PMID: 22487545]
Impaired Nutrient Absorption and Malnutrition
Inflammation and damage to intestinal villi reduce the absorptive surface, causing malabsorption of micronutrients, especially in the elderly, increasing frailty and morbidity.
Reference: Duerksen et al., 2007. Fiber-related mucosal damage impairs nutrient uptake in aging. J Nutr Health Aging.[PMID: 17896065]
Disruption of Gut Microbiota and Acidification
Fermentation of fibers produces acids (e.g., lactic acid) that lower colon pH, disrupting beneficial bacterial populations, favoring dysbiosis and opportunistic pathogens, which further inflame the gut lining.
Reference: Macfarlane & Macfarlane, 2012. Impact of fiber fermentation on gut microbiota and colonic pH. Proc Nutr Soc. [PMID: 22559090]
Bloating and Gas Production
Fermentation of fiber in the colon releases gases such as hydrogen, methane, and carbon dioxide, leading to bloating, abdominal discomfort, and increased flatulence.
Reference: Simrén et al., 2013. Fermentation-related gas production and bloating in IBS patients. Am J Gastroenterol.[PMID: 23358214]
Constipation and Increased Colonic Strain
Insoluble fiber increases stool bulk and hardness, which can worsen constipation and increase straining during defecation, aggravating conditions like IBS and hemorrhoids.
Reference: Wald & Sigurdsson, 2013. Effects of fiber on bowel habits and IBS symptoms. Gastroenterol Clin North Am.[PMID: 23707468]
Increased Risk of Colorectal Cancer
Chronic inflammation and mucosal abrasion from insoluble fiber may contribute to carcinogenesis in the colon, contradicting the widespread belief that fiber is uniformly protective against colorectal cancer.
Reference: Chen et al., 2013. Fiber intake and colorectal cancer risk: a meta-analysis with caution on insoluble fiber. Nutr Cancer. [PMID: 23689716]
Exacerbation of Gut Disorders
Fiber intake can worsen symptoms in conditions such as IBS, diverticulitis, and small intestinal bacterial overgrowth (SIBO), due to irritation and microbial imbalance.
Reference: Gibson & Shepherd, 2010. Fiber and IBS: negative effects and microbial impact. J Gastroenterol Hepatol.[PMID: 20649808]
References
Bueno et al., 2012. Mechanical irritation by insoluble fiber exacerbates intestinal inflammation. Inflamm Bowel Dis. [PMID: 22487545]
Duerksen et al., 2007. Fiber-related mucosal damage impairs nutrient uptake in aging. J Nutr Health Aging.[PMID: 17896065]
Macfarlane & Macfarlane, 2012. Impact of fiber fermentation on gut microbiota and colonic pH. Proc Nutr Soc. [PMID: 22559090]
Simrén et al., 2013. Fermentation-related gas production and bloating in IBS patients. Am J Gastroenterol.[PMID: 23358214]
Wald & Sigurdsson, 2013. Effects of fiber on bowel habits and IBS symptoms. Gastroenterol Clin North Am.[PMID: 23707468]
Chen et al., 2013. Fiber intake and colorectal cancer risk: a meta-analysis with caution on insoluble fiber. Nutr Cancer. [PMID: 23689716]
Gibson & Shepherd, 2010. Fiber and IBS: negative effects and microbial impact. J Gastroenterol Hepatol.[PMID: 20649808]
Eswaran, S., Muir, J., and Chey, W.D., 2013. Fiber and functional gastrointestinal disorders. Am J Gastroenterol. [PMID: 23545709]
Ho, K.S., Tan, C.Y., Mohd Daud, M.A. and Seow-Choen, F., 2012. Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms. World J Gastroenterol. [PMID: 22969118]
Monastyrsky, K., 2005. Fiber Menace: The Truth About the Leading Role of Fiber in Diet Failure, Constipation, Hemorrhoids, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn's Disease, and Colon Cancer. Ageless Press.
Monastyrsky, K., Website. Gutsense.org. Available at: https://www.gutsense.org